Effect of short-term carvedilol therapy on salivary and plasma oxidative stress parameters and plasma glucose level in type II diabetes. Issue 1 (January 2006)

• Record Type: Journal Article
• Authors: Larijani, Bagher; Afshari, Mojgan; Astanehi-Asghari, Fatemeh; Mojtahedi, Alireza; Rezaie, Ali; Hosseinnezhad, Arash; Heshmat, Ramin; Mohammadirad, Azadeh; Abdollahi, Mohammad
• Is Part Of: Therapy. Volume 3:Issue 1(2006)
• Page Start: 119
• Page End: 123
• Publication Date: 2006-01
• Subjects: blood -- carvedilol -- fasting blood sugar -- hemoglobin A1c -- lipid peroxidation -- saliva -- total antioxidant power -- type II diabetes; Therapeutics -- Periodicals; Chemotherapy -- Periodicals; 615.505
• DOI: 10.2217/14750708.3.1.119
• Languages: English
• ISSNs: 1475-0708

Abstract

Background: Type II diabetes is associated with oxidative stress while carvedilol has been shown to have antioxidant properties, which are thought to account for the protective effects.Objective: The objective of this study was to compare the short-term effects of carvedilol versus placebo on oxidative stress status in type II diabetic patients.Methods: A total of 40 patients were randomly allocated to receive carvedilol (6.25 mg three-times daily; n = 20) or placebo (n = 20) for 2 weeks. Fasting blood sugar, hemoglobin A1c, total antioxidant capacity (ferric-reducing ability of plasma test) and lipid peroxidation (thiobarbituric acid reactive substances assay) in plasma and saliva were measured before and after the intervention.Results: No significant difference in oxidative stress status, fasting blood sugar and hemoglobin A1c was observed among the placebo- and carvedilol-treated groups.Conclusion: We conclude that unlike long-term therapy, short-term therapy with carvedilol is incapable of exerting its antioxidant properties and reducing blood sugar levels.