Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest. (19th June 2021)

• Record Type: Journal Article
• Authors: Kuo, Anderson H.; Li, Cun; Huber, Hillary F.; Nathanielsz, Peter W.; Clarke, Geoffrey D.
• Is Part Of: Journal of developmental origins of health and disease. Volume 12:Number 3(2021)
• Page Start: 349
• Page End: 353
• Publication Date: 2021-06-19
• Subjects: Maternal nutrient reduction, -- intrauterine growth restriction (IUGR), -- developmental programming, -- capillary density, -- baboons; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S2040174420000550
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract: Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertension, hypertension, diabetes, hyperlipidemia, and atherosclerosis. We have reported cardiovascular dysfunction in a cohort of maternal nutrient reduction (MNR)-induced intrauterine growth restriction (IUGR) baboon offspring. Here we test the hypothesis that there is oral capillary rarefaction associated with MNR-induced IUGR. Capillary density was quantified using in vivo high-power capillaroscopy on seven middle-aged (~10.7 yr; human equivalent ~40 yr) male IUGR baboons and seven male age-matched controls in the lateral buccal and inferior labial mucosa. While no difference was found between groups in either area by fraction area or optical density for these vascular beds derived from fetal preductal vessels, further studies are needed on post-ductal vascular beds, retina, and function.