Lactobacillus plantarum HFY09 alleviates alcohol‐induced gastric ulcers in mice via an anti‐oxidative mechanism. Issue 5 (13th April 2021) - Wu, Ya
Abstract: The protective effect of Lactobacillus plantarum HFY09 (LP‐HFY09) on alcohol‐induced gastric ulcers was investigated. Gastric morphology observation and pathological tissue sections showed that LP‐HFY09 effectively relieved gastric tissue injury. The biochemical indicator detection showed that LP‐HFY09 increased superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), glutathione (GSH), prostaglandin E2 (PGE2), and somatostatin (SS) levels, and decreased malondialdehyde (MDA) levels. Moreover, LP‐HFY09 inhibited the levels of inflammatory cytokines interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐α (TNF‐α), and elevated the level of anti‐inflammatory cytokine IL‐10. The quantitative polymerase chain reaction (q‐PCR) examination revealed that LP‐HFY09 enhanced the mRNA expression of nuclear factor E2‐related factor 2 (Nrf2) and downstream genes, including copper/zinc superoxide dismutase (SOD1), heme oxygenase‐1 (HO‐1), gamma‐glutamylcysteine synthetase (GSH1), manganese superoxide dismutase (SOD2), catalase (CAT), and GSH‐Px. This study indicated that LP‐HFY09 alleviated alcohol‐induced gastric ulcers by increasing gastric mucosa defense factor, and inhibiting oxidative stress and the inflammatory response. Practical applications: LP‐HFY09 has the potential to be investigated as a treatment for gastric injury induced by alcohol. Abstract : Lactobacillus plantarum HFY09 is a kind of lactic acid bacteria isolated from naturally fermented yoghurt. This study has proved that it can inhibit alcoholic gastric injury and has the potential to be developed as a probiotic.