Cytopathologic findings in histiocytic sarcoma of thyroid mimicking as anaplastic carcinoma: A report of a rare case with review of literature. Issue 6 (5th December 2020)

• Record Type: Journal Article
• Authors: Gupta, Deepika; Gupta, Aanchal; Nalwa, Aasma; Yadav, Taruna; Chaudhary, Ramkaran; Rao, Meenakshi
• Is Part Of: Diagnostic cytopathology. Volume 49:Issue 6(2021)
• Page Start: E218
• Page End: E221
• Publication Date: 2020-12-05
• Subjects: fine‐needle aspiration -- histiocytic sarcoma -- thyroid; Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.24679
• Languages: English
• ISSNs: 8755-1039

Abstract

Abstract: Background: Histiocytic sarcoma is an extremely rare malignant hematological histiocytic neoplasm which is a diagnosis of exclusion based on its morphological and predominantly immunohistochemical criteria. Case Description and Diagnosis: A 63‐year female presented with complaints of a midline neck swelling along with right sided neck swelling. On fine‐needle aspiration (FNA) from the thyroid lesion and the right cervical lymph node, the smears showed similar findings and a provisional morphological diagnosis of malignant spindle cell neoplasm was kept. On immunohistochemistry, the tumor cells showed immunoreactivity for vimentin, CD45, CD 68 and fascin and were immunonegative for thyroglobulin, S100, CD21, CD3, CD4 and other markers. Based on the immunohistochemical profile, a diagnosis of histiocytic sarcoma was established. Conclusion: Histiocytic sarcoma is a rare malignant neoplasm that can be easily missed in thyroid resembling an anaplastic carcinoma.