10% urea cream in senile xerosis: Clinical and instrumental evaluation. (1st May 2021)

• Record Type: Journal Article
• Authors: Lacarrubba, Francesco; Verzì, Anna Elisa; Dinotta, Franco; Micali, Giuseppe
• Is Part Of: Journal of cosmetic dermatology. Volume 20(2021)Supplement 1
• Page Start: 5
• Page End: 8
• Publication Date: 2021-05-01
• Subjects: dermoscopy -- topical treatment -- urea cream -- xerosis; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.14093
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Moisturizers represent the mainstay of treatment of xerosis and related pruritus in elderly patients. Aim: In this study, we evaluated the efficacy and tolerability of a 10% urea cream in patients with senile xerosis. Methods: Twenty patients affected by moderate‐to‐severe xerosis of the upper or lower extremities were enrolled and instructed to apply twice daily for 2 weeks a cream containing 10% urea. Evaluation was performed at baseline and after 7 and 14 days by: clinical examination, itch assessment using a Visual Analogue Scale (VAS), and dermoscopy. Results: After 7 and 14 days of treatment, the tested urea‐based cream resulted in a significant, progressive clinical improvement of xerosis and related pruritus in all patients. The clinical results were supported by dermoscopy that showed the reduction/disappearance of scales. The cream, that had a good cosmetological acceptability, was well tolerated with no report of stinging or burning and/or other side effects. Conclusions: Urea confirms to represent a key molecule for the treatment of senile xerosis.