Novel toxicity of tris(1, 3‐dichloro‐2‐propyl) phosphate in adult male rats. Issue 6 (30th September 2020)

• Record Type: Journal Article
• Authors: Kobayashi, Shohei; Abe, Kodai; Isobe, Anna; Nakayama, Airi; Akimoto, Takahiro; Hatakeyama, Taichi; Saito, Yoshiaki; Yanagisawa, Rie; Koike, Eiko; Suzuki, Noriyuki; Kawaguchi, Maiko; Ohta, Ryo
• Is Part Of: Journal of applied toxicology. Volume 41:Issue 6(2021)
• Page Start: 987
• Page End: 992
• Publication Date: 2020-09-30
• Subjects: ALP -- anti‐androgenic chemical -- flame retardant -- renal anemia -- reticulocyte count -- TDCIPP; Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.4075
• Languages: English
• ISSNs: 0260-437X

Abstract

Abstract: The widespread use of tris(1, 3‐dichloro‐2‐propyl) phosphate (TDCIPP) as a flame retardant has led to its release to the environment. Thus, the toxicological effects of TDCIPP on humans and animals are of importance. For better understanding of its potential toxicities, TDCIPP (250, 500, or 650 mg/kg/day) or vehicle control was administrated orally to adult male Wistar‐Imamichi rats for 7 days. After the final administration of compounds, organ weights, histopathology, blood biochemistry, and hematology were examined. Hepatic toxicity was observed at doses ≥ 500 mg/kg/day of TDCIPP, and renal toxicity was observed at 650 mg/kg/day. The anti‐androgenic activity of TDCIPP was previously confirmed in vitro and in vivo, but weights of epididymis, an androgen‐dependent organ, were not affected by TDCIPP treatment in adults. Serum alkaline phosphatase activity was significantly decreased in all TDCIPP‐treated rats independent of dose. Hemoglobin concentration, hematocrit, red blood cell count, and reticulocyte count were decreased in all TDCIPP‐treated rats, but mean corpuscular volume, total iron‐binding capacity, and serum iron were normal, suggesting that renal anemia was caused by TDCIPP. Together with previous reports on effects of anti‐androgenic substances on red blood cell indices, anemia caused by TDCIPP could be due to its anti‐androgenic activity. These considerations will contribute to further assessment of the toxicity of the compound. Abstract : Tris(1, 3‐dichloro‐2‐propyl) phosphate (TDCIPP) was administrated orally to adult male Wistar‐Imamichi rats for 7 days. Serum ALP activity was significantly decreased in all TDCIPP‐treated rats independent of dose. Hemoglobin concentration, hematocrit, red blood cell count, and reticulocyte count were decreased by TDCIPP, suggesting that renal anemia is possibly caused by its anti‐androgenic activity. These considerations will contribute to further assessment of the toxicity of the compound.