Front Cover: Simultaneous determination of erythrocyte methotrexate polyglutamates by a novel and simple HPLC‐MS/MS method with stable isotope‐labeled internal standards. Issue 9 (8th May 2021)

• Record Type: Journal Article
• Authors: Wu, Jingjing; Zhang, Song; Li, Jiali; Zhong, Xiaoli; Feng, Guiping; Hu, Liangqing; He, Fan; Cen, Hanjing; Chen, Yilu; He, Yanling; Zeng, Huasong; Chen, Xiao; Mo, Xiaolan
• Is Part Of: Journal of separation science. Volume 44:Issue 9(2021)
• Page Start: NA
• Page End: NA
• Publication Date: 2021-05-08
• Subjects: Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.202170091
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract : DOI: 10.1002/jssc.202001081 The cover picture shows a new HPLC strategy for quantitative analysis of multiple components via a single marker (QAMS) to determine nine nucleosides (cytidine, uridine, 2'‒deoxyuridine, inosine, guanosine, 2'‒deoxyguanosine, thymidine, adenosine and 2'‒deoxyadenosine) in Rhizoma Paridis for the first time. The results of methodology validation showed that there was no significant difference between QAMS method and the external standard method, indicating that QAMS method can applied to solve the problem of a shortage of reference materials and high cost in multicomponent analysis. Our work provide an efficient and feasible quality assessment method for other natural products containing nucleosides.