Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion. Issue 24 (19th April 2021)

• Record Type: Journal Article
• Authors: Liu, Meina; Ucar, Esma; Liu, Ziang; Wang, Lei; Yang, Li; Xu, Jiawei; Akkaya, Engin U.
• Is Part Of: RSC advances. Volume 11:Issue 24(2021)
• Page Start: 14513
• Page End: 14516
• Publication Date: 2021-04-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra02569d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Singlet oxygen generated by the cycloreversion of endoperoxides has anti-coagulant activity. Abstract : Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1, 4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen.