Antifouling fluoropolymer-coated nanomaterials for 19F MRI. Issue 38 (14th April 2021)

• Record Type: Journal Article
• Authors: Jirak, Daniel; Svoboda, Jan; Filipová, Marcela; Pop-Georgievski, Ognen; Sedlacek, Ondrej
• Is Part Of: Chemical communications. Volume 57:Issue 38(2021)
• Page Start: 4718
• Page End: 4721
• Publication Date: 2021-04-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00642h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Multifunctional polymer coating for gold nanoparticles enables simultaneous 19 F MRI tracing and shielding from blood plasma fouling. Abstract : We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by 19 F MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly( N -(2-fluoroethyl)acrylamide) (PFEAM) that shows high 19 F MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol. A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by 19 F MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification.