Evaluation of production cross-sections for theranostic 67Cu radionuclide via proton-induced nuclear reaction on 68Zn target. (July 2021)

• Record Type: Journal Article
• Authors: Ali, Samer K.I.; Khandaker, Mayeen Uddin; Al-mugren, K.S.; Latif, Sk.A.; Bradley, D.A.; Okhunov, A.A.; Sulieman, A.
• Is Part Of: Applied radiation and isotopes. Volume 173(2021)
• Publication Date: 2021-07
• Subjects: Radioimmunotherapy -- 67Cu -- β̶-γ emitter -- SOK code -- Evaluated data -- Nuclear reaction cross-section -- TALYS and EMPIRE codes; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2021.109735
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Copper-67 ( T 1/2 = 61.83 h, E β − m e a n = 141 keV, I β − t o t a l = 100%; E γ = 184.577 keV, I γ = 48.7%) is a promising radionuclide for theranostic applications especially in radio immunotherapy. However, one of the main drawbacks for its application is related to its limited availability. Various nuclear reaction routes investigated in the last years can result in 67 Cu production, although the use of proton beams is the method of choice taken into account in this work. The goal of this work is a revision of the cross-sections aimed at 67 Cu yield, which were evaluated for the 68 Zn(p, 2p) 67 Cu reaction route up to 80 MeV proton energy. A well-defined statistical procedure, i.e., the Simultaneous Evaluation on KALMAN (SOK), combined with the least-squares concept, was used to obtain the evaluated data together with the covariance matrix. The obtained evaluated data were also compared to predictions provided by the nuclear reaction model codes TALYS and EMPIRE, and a partial agreement among them has been found. These data may be useful for both existing and potential applications in nuclear medicine, to achieve an improvement and validation of the various nuclear reaction models, and may also find applications in other fields (e.g., activation analysis and thin layer activation). Highlights: Based on some favorable criteria, the 68 Zn(p, 2p) 67 Cu reaction was selected for evaluation. Data were renormalized based on the latest decay data and monitor reactions. SOK code combined with least-squares method was applied to the corrected data. Evaluated data with covariance matrix are generated and reported herein. A partial agreement are found among the evaluated data, and predictions of model codes TALYS and EMPIRE.