Silk‐Inspired In Situ Hydrogel with Anti‐Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing. (23rd February 2021)

• Record Type: Journal Article
• Authors: Tang, Xiaoxuan; Chen, Xiaoli; Zhang, Siming; Gu, Xinyi; Wu, Ronghua; Huang, Tingting; Zhou, Zhihao; Sun, Cheng; Ling, Jue; Liu, Mei; Yang, Yumin
• Is Part Of: Advanced functional materials. Volume 31:Number 17(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-23
• Subjects: anti‐tumor immunity -- melanoma -- photodynamic therapy -- silk fibroin -- wound healing; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202101320
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) and chlorine e6 for improved cancer therapy with enhanced wound healing is developed. Favored by the macrophage recruitment capacity of the SF hydrogel, promising antitumor immune responses can be turned "on" via near infrared irradiation in a controllable manner to achieve combination therapy with photodynamic therapy to significantly suppress melanoma recurrence. Moreover, the effective photodynamic antibacterial activity of this bioactive system with the capacity of light‐controllable modulating macrophage phenotype promotes remarkable tissue ingrowth with hair follicle regeneration for Staphylococcus aureus infected wound healing. Thus, this multifunctional silk‐based hydrogel system, as a desirable wound dressing, provides a new platform for promising melanoma therapy and skin regeneration. Abstract : A silk fibroin methacrylate‐chlorine e6 hydrogel with in situ gelation capacity can successfully recruit macrophages and provide light‐controllable macrophage activation with photodynamic therapy to achieve enhanced therapy for melanoma. Moreover, the hydrogel system holds promising photodynamic antibacterial activity to promote infected wound healing, which may serve as a powerful tool for current postoperative treatment of melanoma.