Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury. Issue 9 (8th April 2021)

• Record Type: Journal Article
• Authors: Wei, Guan; Wang, Jiawei; Wu, Yanbin; Zheng, Xiaoxin; Zeng, Yile; Li, Yasong; Chen, Xiangrong
• Is Part Of: Journal of cellular and molecular medicine. Volume 25:Issue 9(2021)
• Page Start: 4478
• Page End: 4486
• Publication Date: 2021-04-08
• Subjects: neuroinflammation -- neuronal apoptosis -- NF‐κB -- sirtuin 1 -- traumatic brain injury; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.16534
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: Sirtuin 1 (SIRT1) plays a very important role in a wide range of biological responses, such as metabolism, inflammation and cell apoptosis. Changes in the levels of SIRT1 have been detected in the brain after traumatic brain injury (TBI). Further, SIRT1 has shown a neuroprotective effect in some models of neuronal death; however, its role and working mechanisms are not well understood in the model of TBI. This study aimed to address this issue. SIRT1‐specific inhibitor (sirtinol) and activator (A3) were introduced to explore the role of SIRT1 in cell apoptosis. Results of the study suggest that SIRT1 plays an important role in neuronal apoptosis after TBI by inhibiting NF‐κB, IL‐6 and TNF‐α deacetylation and the apoptotic pathway sequentially, possibly by alleviating neuroinflammation.