New metabolites produced by endophyte Clonostachys rosea B5 − 2. Issue 9 (3rd May 2021)

• Record Type: Journal Article
• Authors: Supratman, Unang; Suzuki, Takuma; Nakamura, Tomoki; Yokoyama, Yasuhiro; Harneti, Desi; Maharani, Rani; Salam, Supriatno; Abdullah, Fajar Fauzi; Koseki, Takuya; Shiono, Yoshihito
• Is Part Of: Natural product research. Volume 35:Issue 9(2021)
• Page Start: 1525
• Page End: 1531
• Publication Date: 2021-05-03
• Subjects: Endophyte -- Clonostachys rosea -- OSMAC -- (-)-Vertinolide -- phytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1656629
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The endophytic fungus, Clonostachys rosea B5-2 was isolated from mangrove plants and subjected to the one strain many compounds (OSMAC) methodology. By this approach, it was found that modification of the culture media enhanced the production of secondary metabolites by C. rosea B5-2. The apple juice supplemented solid rice media led to significant changes in the secondary metabolism of the fungus, C. rosea B5-2, and induced the production of four new compounds, (-)-dihydrovertinolide (2 ), and clonostach acids A (3 ), B (4 ), and C (5 ) together with the known compound, (-)-vertinolide (1 ). The new compound (-)-dihydrovertinolide (2 ) exhibited phytotoxicity against lettuce seedlings at a concentration of 50 mg L −1 . Abstract :