Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity. Issue 9 (3rd May 2021)

• Record Type: Journal Article
• Authors: Wang, Haixia; Huang, Huiming; Lv, Jingwei; Jiang, Ning; Li, Yujiao; Liu, Xinmin; Zhao, Hongping
• Is Part Of: Natural product research. Volume 35:Issue 9(2021)
• Page Start: 1544
• Page End: 1549
• Publication Date: 2021-05-03
• Subjects: Gentianaceae -- NMR spectroscopy -- Swertia mussotii -- secoiridoid -- antitumor activity assay; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1660332
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new secoiridoid compound swertiamarin B (1 ), along with a known compound lytanthosalin (2 ), were isolated from ethanol extract of the aerial parts of Swertia mussotii . Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were first isolated from the Swertia genus. Their antitumor activities were evaluated for four human tumor cell lines (HCT-116, HepG2, MGC-803 and A549). Compounds 1 and 2 showed excellent cytotoxic activities toward the MGC-803 cell lines with IC50 values 3.61 and 12.04 μM, respectively. Abstract :