Pyrrolizidine alkaloids from the seeds of Scleropyrum wallichianum. Issue 5 (4th May 2021)

• Record Type: Journal Article
• Authors: Liu, Jun-Hong; Yang, Han; Zhang, Ling; Peng, Xing-Rong; Li, Zhen-Jie; He, Mei-Ying; Wan, Luo-Sheng; Li, Zhong-Rong; Zhou, Lin; Liu, Zhi-Hua; Qiu, Ming-Hua
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 5(2021)
• Page Start: 407
• Page End: 413
• Publication Date: 2021-05-04
• Subjects: Scleropyrum wallichianum -- pyrrolizidine alkaloids -- cytotoxicities; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1740919
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new pyrrolizidine alkaloids, sclerwalins A and B (1 and 2 ), and one known 9-O-E-hydroxysenecioylretronecine (3 ) were first isolated from the seeds of Scleropyrum wallichianum . Their chemical structures were elucidated by extensive 1 D NMR and 2 D NMR (HSQC, HMBC, COSY, and ROESY), MS and IR spectra. Cytotoxicities of all isolates were evaluated against five human tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW480).