Solvent effect, transfer property and preferential solvation of artesunate in aqueous co-solvent mixtures of some alcohols. (4th May 2021)

• Record Type: Journal Article
• Authors: Li, Wanxin; Xing, Rong; Zhu, Yiting; Farajtabar, Ali; Zhao, Hongkun
• Is Part Of: Physics and chemistry of liquids. Volume 59:Number 3(2021)
• Page Start: 454
• Page End: 466
• Publication Date: 2021-05-04
• Subjects: Artesunate -- preferential solvation -- transfer property -- solvent effect; Liquids -- Periodicals; 530.4205
• DOI: 10.1080/00319104.2020.1732374
• Languages: English
• ISSNs: 0031-9104

Abstract

ABSTRACT: The preferential solvation of artesunate in mixtures of ethanol (1) + water (2), methanol (1) + water (2), propylene glycol (PG, 1) + water (2) and isopropanol (1) + water (2) was investigated through the obtainable solubility data by the method of inverse Kirkwood–Buff integrals. In co-solvent-rich and intermediate compositions, artesunate was preferentially solvated by the co-solvent (methanol, ethanol or isopropanol). However, artesunate was not preferentially solvated by the solvent PG. A quantitative description of the solvent effect was obtained by modelling the change in Gibbs-free energy of solubility using linear solvation energy relationships. In addition, the transfer properties such as enthalpy, Gibbs-free energy and entropy were resulted.