Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ42 protofibril. Issue 35 (31st March 2021)
- Record Type:
- Journal Article
- Title:
- Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ42 protofibril. Issue 35 (31st March 2021)
- Main Title:
- Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ42 protofibril
- Authors:
- Zhan, Chendi
Lao, Zenghui
Tang, Yiming
Qiao, Qin
Wei, Guanghong - Abstract:
- Abstract : Stereoisomers (+)-C and (−)-C show a better disruptive effect on Aβ42 protofibril than EC due to the steric effect caused by the conformational differences. Abstract : Our simulations reveal that two enantiomeric catechins display a better disruptive effect on Aβ42 protofibril than their stereoisomer epicatechin. Unexpectedly, we find that catechins adopt both collapsed and extended states, while epicatechin populates only an extended state. Their different protofibril-disruptive effects are mostly attributed to the steric effect caused by the conformational differences.
- Is Part Of:
- Chemical communications. Volume 57:Issue 35(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 35(2021)
- Issue Display:
- Volume 57, Issue 35 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 35
- Issue Sort Value:
- 2021-0057-0035-0000
- Page Start:
- 4267
- Page End:
- 4270
- Publication Date:
- 2021-03-31
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc00404b ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16727.xml