Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications. Issue 35 (6th April 2021)

• Record Type: Journal Article
• Authors: Wang, Shiqi; Fontana, Flavia; Shahbazi, Mohammad-Ali; Santos, Hélder A.
• Is Part Of: Chemical communications. Volume 57:Issue 35(2021)
• Page Start: 4212
• Page End: 4229
• Publication Date: 2021-04-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00811k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Ac-DEX and its functional derivatives have been formulated as nano- or microparticles for drug delivery applications in the biomedical field. Abstract : Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus on the chemical synthesis, nano- and micro-particle fabrication techniques, the controlled-release mechanisms, and the rational design Ac-DEX-based of drug delivery systems in various biomedical applications. Finally, we briefly discuss the challenges and future perspectives in the field.