A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity. Issue 17 (23rd April 2021)
- Record Type:
- Journal Article
- Title:
- A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity. Issue 17 (23rd April 2021)
- Main Title:
- A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity
- Authors:
- Johnson, Alice
Iffland, Linda
Singh, Kuldip
Apfel, Ulf-Peter
Suntharalingam, Kogularamanan - Abstract:
- Abstract : A cancer stem cell (CSC) active, solution stable, silver(i ) polymeric complex bearing a dithiacyclam ligand is reported. Abstract : A cancer stem cell (CSC) active, solution stable, silver(i ) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.
- Is Part Of:
- Dalton transactions. Volume 50:Issue 17(2021)
- Journal:
- Dalton transactions
- Issue:
- Volume 50:Issue 17(2021)
- Issue Display:
- Volume 50, Issue 17 (2021)
- Year:
- 2021
- Volume:
- 50
- Issue:
- 17
- Issue Sort Value:
- 2021-0050-0017-0000
- Page Start:
- 5779
- Page End:
- 5783
- Publication Date:
- 2021-04-23
- Subjects:
- Chemistry, Inorganic -- Periodicals
Chemistry, Physical and theoretical -- Periodicals
Chemistry, Inorganic -- Periodicals
546.05 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/dt#!issueid=dt043040&type=current&issnprint=1477-9226 ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1dt01155c ↗
- Languages:
- English
- ISSNs:
- 1477-9226
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3517.830000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16710.xml