Pd-Catalyzed double carbopalladation/syn-insertion cascade reactions toward medium-size sulfoximine heterocycles. Issue 35 (31st March 2021)

• Record Type: Journal Article
• Authors: Dai, Longji; Yuan, Jianjun; Wu, Cui; Chen, Zhiyuan
• Is Part Of: Chemical communications. Volume 57:Issue 35(2021)
• Page Start: 4271
• Page End: 4274
• Publication Date: 2021-03-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00846c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : With the application of Ac in sulfoximine as a protecting group (PG) and MeOH as a de-PG agent, Pd-catalyzed multicomponent reactions were developed to access indene-fused medium-size sulfoximine heterocycles. Abstract : With the assistance of Ac in sulfoximine as a protecting group (PG) and MeOH as a de-PG agent, Pd-catalyzed multicomponent reactions were developed to access indene-fused medium-size sulfoximine heterocycles. The reactions proceeded smoothly under exceptionally mild conditions to produce polyheterocyclic sulfoximines with regiospecificity and good functional group tolerance. A double carbopalladation/ syn -insertion of triple bond sequences was proposed tothis transformation.