PS02.074: ENDOSCOPIC TUMOUR MORPHOLOGY AFFECTS SURVIVAL IN OESOPHAGEAL CANCER. (14th September 2018)

• Record Type: Journal Article
• Authors: Habib, Wais; Zylstra, Janine; Knight, William; Bott, Rebecca; Mahadeva, Ula; Davies, Andrew; Gossage, James
• Is Part Of: Diseases of the esophagus. Volume 31(2018)Supplement 1
• Page Start: 141
• Page End: 141
• Publication Date: 2018-09-14
• Subjects: oesophageal cancer -- Endoscopic tumour morphology; Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doy089.PS02.074
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract: Background: Oesophageal carcinoma can present with a variety of endoscopic morphologies. No previous studies have ascertained whether endoscopic tumour morphology impacts survival. This study describes three distinct endoscopic tumour morphologies; ulcerating, exophytic and stenosing, and analyses their impact on survival. Methods: This is a retrospective cohort study of 181 patients who underwent diagnostic endoscopy prior to oesophagectomy at St Thomas' Hospital, London. Univariable and multivariable Cox regression analyses were performed to determine hazard ratios (HR) with 95% confidence intervals for overall survival. Results: There were 56 ulcerating, 68 exophytic and 57 stenosing lesions. Median survival was 52.7 months for ulcerating lesions, 46.8 months for exophytic lesions and 33.8 months for stenosing lesions ( P = 0.01). When compared to stenosing lesions, exophytic and ulcerating lesions demonstrated a significant survival advantage on univariable analysis (exophytic HR 0.53; 95%CI 0.21–0.95, ulcerating HR 0.37; 95%CI 0.19–0.73). Conclusion: This study demonstrates that endoscopic morphology may be an important prognostic factor in oesophageal cancer. Further studies are needed to confirm whether this is an independent prognostic indicator which may help guide future neoadjuvant and surgical treatment strategies. Disclosure: All authors have declared no conflicts of interest.