Development and application of several fluorescent probes in near infrared region. (June 2021)

• Record Type: Journal Article
• Authors: Wang, Yuesong; Yu, Haoli; Zhang, Yong; Jia, Chengli; Ji, Min
• Is Part Of: Dyes and pigments. Volume 190(2021)
• Publication Date: 2021-06
• Subjects: NIR -- Fluorescent -- Probe -- Detection limit; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2021.109284
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Life in the body depends on the regulation of various substances, including metal ions, anions, enzymes, thiols, ROS/RNS and so on. Fluorescent probe can be used for quantitative and qualitative analysis of various analytes. Near–infrared (NIR) fluorescent probes have been widely used because of the advantages of less background interference, stronger tissue penetration, and less tissue damage. In this paper, the research progress (2016–2020) and biological applications of NIR fluorescent probes based on different mechanisms are reviewed. Special emphasis is placed on the principle of fluorescence generation and the design strategies of different response mechanisms. At the same time, the detection system, detection limit and emission wavelength of the probes responding to the same type of analytes are compared, and the development trend of NIR fluorescent probes in the future is discussed. Graphical abstract: This article summarizes the detection of different analytes by near–infrared fluorescent probes in the past five years (2016–2020), including metal ions, anions, enzymes, thiols, and ROS/RNS. At the same time, it summarizes the probes that recognize the same type of analyte and compares their performance. Image 1 Highlights: The near–infrared fluorescent probe summarized is relatively new, and it is in the last five years (2016–2020). In terms of analytes, a comprehensive summary is made, including metal ions, anions, enzymes, thiols, ROS/RNS. The principle of fluorescence generation and part of response mechanism are pointed out in this paper.