Synthesis of chryseno[1, 2-b]heteroarenes and phenanthro[1, 2-b:8, 7-b']diheteroarenes by an SNAr-anionic cyclization cascade reaction strategy. Issue 52 (24th December 2020) - Gilmore, James
Graphical abstract: Abstract: The synthesis of [5]heterophenacenes bearing one or two indole, furan, or thiophene rings is described using an SN Ar-anionic cyclization cascade strategy. The convergent reaction sequences furnish chryseno[1, 2- b ]heteroarenes and phenanthro[1, 2- b :8, 7- b' ]diheteroarenes in only four synthetic steps. The heteroaromatic functionality is selected and installed in the final step of the syntheses from common ortho -fluoro-ethynylarene precursors.