Blood biomarkers for differential diagnosis and early detection of pancreatic cancer. (May 2021)

• Record Type: Journal Article
• Authors: Al-Shaheri, Fawaz N.; Alhamdani, Mohamed S.S.; Bauer, Andrea S.; Giese, Nathalia; Büchler, Markus W.; Hackert, Thilo; Hoheisel, Jörg D.
• Is Part Of: Cancer treatment reviews. Volume 96(2021)
• Publication Date: 2021-05
• Subjects: Pancreatic cancer -- Liquid biopsy -- Blood-based biomarkers -- Proteins -- microRNAs -- Circulating tumor DNA (ctDNA) -- Circulating tumor cells -- Differential diagnosis -- Early detection; Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2021.102193
• Languages: English
• ISSNs: 0305-7372

Abstract

Graphical abstract: Highlights: Pancreatic cancer is the most lethal tumor with mortality close to incidence. Blood-based diagnostics could have a very strong impact on changing this. We are reviewing the current state of affairs in a comprehensive manner. Also, we are proposing steps toward clinical utility. Many of the conclusions are likely to be relevant to other solid tumors, too. Abstract: Pancreatic cancer is currently the most lethal tumor entity and case numbers are rising. It will soon be the second most frequent cause of cancer-related death in the Western world. Mortality is close to incidence and patient survival after diagnosis stands at about five months. Blood-based diagnostics could be one crucial factor for improving this dismal situation and is at a stage that could make this possible. Here, we are reviewing the current state of affairs with its problems and promises, looking at various molecule types. Reported results are evaluated in the overall context. Also, we are proposing steps toward clinical utility that should advance the development toward clinical application by improving biomarker quality but also by defining distinct clinical objectives and the respective diagnostic accuracies required to achieve them. Many of the discussed points and conclusions are highly relevant to other solid tumors, too.