Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. Issue 4 (19th August 2017)

• Record Type: Journal Article
• Authors: Peng, Guangdun; Tam, Patrick P. L.; Jing, Naihe
• Is Part Of: National science review. Volume 4:Issue 4(2017:Jul.)
• Page Start: 533
• Page End: 542
• Publication Date: 2017-08-19
• Subjects: early development -- cell lineage -- cell identity -- scRNA-seq -- spatial transcriptome; Science -- Periodicals; 505
• DOI: 10.1093/nsr/nwx093
• Languages: English
• ISSNs: 2095-5138

Abstract

Abstract: Establishment of progenitor cell populations and lineage diversity during embryogenesis and the differentiation of pluripotent stem cells is a fascinating and intricate biological process. Conceptually, an understanding of this developmental process provides a framework to integrate stem-cell pluripotency, cell competence and differentiating potential with the activity of extrinsic and intrinsic molecular determinants. The recent advent of enabling technologies of high-resolution transcriptome analysis at the cellular, population and spatial levels proffers the capability of gaining deeper insights into the attributes of the gene regulatory network and molecular signaling in lineage specification and differentiation. In this review, we provide a snapshot of the emerging enabling genomic technologies that contribute to the study of development and stem-cell biology.