The different phenotypes of COPD. (10th March 2021)

• Record Type: Journal Article
• Authors: Yousuf, Ahmed; McAuley, Hamish; Elneima, Omer; Brightling, Christopher E
• Is Part Of: British medical bulletin. Volume 137(2021)
• Page Start: 82
• Page End: 97
• Publication Date: 2021-03-10
• Subjects: COPD -- phenotype -- eosinophils -- acute exacerbation -- CRP -- PCT; Medicine -- Periodicals; 610.5
• DOI: 10.1093/bmb/ldaa043
• Languages: English
• ISSNs: 0007-1420

Abstract

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality. To improve the health status and reduce symptom burden, it is important to identify a group of patients with similar characteristics and prognosis, called clinical phenotypes. Herein we shall review the different phenotypes of COPD. Sources of data: Keywords (COPD, phenotype, acute exacerbation) search was conducted in PubMed, Google Scholar. Areas of agreement: Those with raised blood eosinophil counts respond better to steroid therapy at stable state and exacerbation. Areas of controversy: There is no universally accepted blood eosinophil cut-off value that will indicate favourable response to corticosteroids and potentially for future biologic therapy. Growing points: There is an urgent need for further therapeutic options for COPD patients with non-eosinophilic inflammation. Areas timely for developing research: Well-designed COPD trials with identification of phenotypes for more personalization of the treatment of COPD.