Accelerating endothelialization of coronary stents by capturing circulating endothelial progenitor cells. (April 2012)

• Record Type: Journal Article
• Authors: Yazdani, Saami K; Nakano, Masataka; Otsuka, Fumiyuki; Kolodgie, Frank D; Virmani, Renu
• Is Part Of: Interventional cardiology. Volume 4:Number 2(2012)
• Page Start: 169
• Page End: 181
• Publication Date: 2012-04
• Subjects: coronary stent -- endothelial progenitor cell -- endothelialization -- late stent thrombosis; Cardiology -- Periodicals; Coronary heart disease -- Treatment -- Periodicals; 616.1205
• DOI: 10.2217/ica.11.99
• Languages: English
• ISSNs: 1755-5310

Abstract

Drug-eluting stents (DES) have become the standard of care for the treatment of coronary artery disease. However, late stent thrombosis has emerged as a major concern, especially in 'off-label'' use. Pathologic studies of patients dying from late DES thrombosis demonstrate delayed arterial healing, characterized by persistent fibrin deposition and poor endothelialization. In recent years, a novel prohealing device was developed that captures circulating endothelial progenitor cells (EPCs) by immobilized antihuman-CD34 antibody as a surface coating. EPCs have the ability to migrate to areas of vascular injury and aid in the regeneration of damaged and dysfunctional endothelium. Preclinical results of the EPC-capture stent have shown promise in accelerating endothelialization as compared with bare metal and DES. Clinically, the safety and efficacy of the EPC-capture stent has been proven in numerous clinical trials with low incidence of late stent thrombosis. In this article, we discuss the relevance of the EPC-capture technology and the significance of current preclinical and clinical studies.