Water-soluble and biocompatible sono/photosensitizer nanoparticles for enhanced cancer therapy. (December 2010)

• Record Type: Journal Article
• Authors: Meng, Yongde; Zou, Chunpu; Madiyalakan, Ragupathy; Woo, Thomas; Huang, Min; Yang, Xiaoyan; Swanson, Eric; Chen, Jie; Xing, James Z
• Is Part Of: Nanomedicine. Volume 5:Number 10(2010)
• Page Start: 1559
• Page End: 1569
• Publication Date: 2010-12
• Subjects: cancer sonodynamic/photodynamic -- drug delivery -- nanocarrier -- polyvinylpyrollidone formulated nanoparticles -- sono/photosensitizer therapy; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.10.91
• Languages: English
• ISSNs: 1743-5889

Abstract

Aims: Most sono/photosensitizers of cancer sonodynamic/photodynamic therapy (SDT/PDT), such as hypocrellin SL052, are water-insoluble, therefore restricting their clinical applications. In this article, we present a water-soluble nanocarrier to load the SDT/PDT sensitizer SL052 with improved pharmacokinetics and therapeutic efficacy.Materials & methods: Nanoclusters of polyvinylpyrrolidones with SL052 formed water-soluble nanoparticles (SL052-NPs) while retaining the chemical structure of SL052.Results: The experimental results show that SL052-NPs improve the drug''s physicochemical properties and significantly enhance the efficacy of SL052 in terms of pharmacokinetics and cancer killing. Water-soluble SL052-NPs can be used to deliver the drug to deep cancer tissues. A potential benefit of SL052-NPs is that polyvinylpyrrolidones can help SL052 evade the reticuloendothelial system, thereby increasing circulation half-life and improving drug biodistribution.Conclusion: SL052-NPs greatly improved the physicochemical properties of SL052 without modifying its chemical structure, allowing for deep-site cancer drug delivery, imaging for diagnosis, and ultrasound or photocontrolled localized cancer therapy.