The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation. Issue 36 (21st August 2019)

• Record Type: Journal Article
• Authors: Lejault, Pauline; Duskova, Katerina; Bernhard, Claire; Valverde, Ibai E.; Romieu, Anthony; Monchaud, David
• Is Part Of: European journal of organic chemistry. Issue 36(2019)
• Page Start: 6146
• Page End: 6157
• Publication Date: 2019-08-21
• Subjects: Polyazamacrocycles -- Molecular platforms -- Multivalency -- Theranostics -- Bioactive compounds; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201900870
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Recent advances in the use of radiometals for both imaging and therapy has spurred on the development of an original chemistry that endows radionuclide‐chelating molecular cages with ever sharper physicochemical properties. Macrocyclic polyamines (MPAs) such as cyclen and DOTA are among the most frequently encountered cages for the design of new radiotracers, owing to their versatile chemistry that makes them customizable molecular tools. The idea of using MPAs for alternative purposes has recently emerged, with an eye towards benefiting from their unique topology, versatility, symmetry and water‐solubility. This review summarizes strategies that have been recently implemented in which MPAs are used as multivalent molecular platforms for constructing sophisticated suprastructures that found applications in various fields, from materials chemistry to chemical biology. These original approaches are invaluable in that they successfully expand the scope of applications of MPAs far beyond their restricted roles of metal chelating appendages. Abstract : No metal, no cry! Macrocyclic polyamines (MPAs) are important chelating agents for cations, anions, and neutral molecules; cyclen and DOTA are well‐known contrast agents for MR or PET/SPECT imaging. Their unique properties also make them attractive multivalent molecular platforms for applications far beyond conventional metal chelation. Their use in materials chemistry, medicinal chemistry, and chemical biology is discussed.