From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. (December 2011)

• Record Type: Journal Article
• Authors: McDonagh, Ellen M; Whirl-Carrillo, Michelle; Garten, Yael; Altman, Russ B; Klein, Teri E
• Is Part Of: Biomarkers in medicine. Volume 5:Number 6(2011)
• Page Start: 795
• Page End: 806
• Publication Date: 2011-12
• Subjects: Clinical Annotations -- Clinical Interpretations -- genomic variation -- pharmacogenetics -- pharmacogenomics -- Pharmacogenomics Knowledge Base -- PharmGKB -- Variant Annotations; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.11.94
• Languages: English
• ISSNs: 1752-0363

Abstract

The mission of the Pharmacogenomics Knowledge Base (PharmGKB;www.pharmgkb.org ) is to collect, encode and disseminate knowledge about the impact of human genetic variations on drug responses. It is an important worldwide resource of clinical pharmacogenomic biomarkers available to all. The PharmGKB website has evolved to highlight our knowledge curation and aggregation over our previous emphasis on collecting primary data. This review summarizes the methods we use to drive this expanded scope of 'Knowledge Acquisition to Clinical Applications'', the new features available on our website and our future goals.