An update: mechanisms of microRNA in primary open-angle glaucoma. (9th November 2020)

• Record Type: Journal Article
• Authors: Wang, Yuanping; Niu, Lingzhi; Zhao, Jing; Wang, Mingxuan; Li, Ke; Zheng, Yajuan
• Is Part Of: Briefings in functional genomics. Volume 20:Number 1(2021)
• Page Start: 19
• Page End: 27
• Publication Date: 2020-11-09
• Subjects: POAG -- NTG -- microRNA -- SNP -- diagnosis; Genomics -- Methodology -- Periodicals; Genomics -- Technological innovations -- Periodicals; 572.86072
• DOI: 10.1093/bfgp/elaa020
• Languages: English
• ISSNs: 2041-2649

Abstract

Abstract: Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.