Preparation, characterisation, drug loading and release properties of a novel KIT‐6/poly(AA‐EGDMA) nanocomposite. (1st February 2018)

• Record Type: Journal Article
• Authors: Shafiei, Anahita; Yahya, S.; Beheshtiha, Sh.; Heravi, Majid M.; Kalbasi, Roozbeh Javad
• Is Part Of: Micro & nano letters. Volume 13:Number 2(2018)
• Page Start: 213
• Page End: 218
• Publication Date: 2018-02-01
• Subjects: drug delivery systems -- nanocomposites -- filled polymers -- mesoporous materials -- silicon compounds -- nanomedicine -- biomedical materials -- nanofabrication -- polymerisation -- sol‐gel processing -- Fourier transform infrared spectra -- X‐ray diffraction -- thermal analysis -- scanning electron microscopy -- ultraviolet spectra -- visible spectra -- adsorption; SiO2 -- thermal gravimetric analysis -- simulated body fluid -- drug adsorption -- time‐loading -- polymer -- ultraviolet‐visible spectroscopy -- scanning electron microscopy -- Brunauer‐Emmett‐Teller specific surface areas -- X‐ray powder diffraction -- Fourier transform infrared spectroscopy -- ibuprofen system -- mesostructure -- KIT‐6 pores -- in situ method -- polymerisation -- sol‐gel method -- three‐dimensional cubic symmetric structure -- KIT‐6‐poly(acrylic acid‐ethylene glycol dimethacrylate) nanocomposite -- KIT‐6‐poly(AA‐EGDMA) nanocomposite -- drug release properties -- drug loading properties; Nanotechnology -- Periodicals; Nanostructures -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1049/mnl.2017.0451
• Languages: English
• ISSNs: 1750-0443

Abstract

Abstract : A KIT‐6/poly(acrylic acid‐ethylene glycol dimethacrylate) (KIT‐6/Poly(AA‐EGDMA) nanocomposite was synthesised as an adequate carrier. KIT‐6 as a three‐dimensional cubic symmetric structure was prepared by the sol–gel method. Polymerisation was carried out through the in situ method in which EGDMA was cross‐linked by AA inside KIT‐6 pores. This mesostructure acts as a smart uptake and release of the ibuprofen (IBU) system. Diverse characterisation techniques including Fourier transform infrared spectroscopy, X‐ray powder diffraction, Brunauer–Emmett–Teller, thermal gravimetric, scanning electron microscopy and ultraviolet‐visible spectroscopy were employed to determine the relationship between the carrier nature and drug release performance. The KIT‐6/Poly(AA‐EGDMA) was modified by changing the ratio of the polymer and IBU as well as its time‐loading. The results proved that the KIT‐6/Poly(AA‐EGDMA) has the ability of drug adsorption and slow release in a simulated body fluid.