Brain targeting by intranasal drug delivery (INDD): a combined effect of trans-neural and para-neuronal pathway. (23rd March 2016)

• Record Type: Journal Article
• Authors: Mustafa, Gulam; Alrohaimi, Abdulmohsen H.; Bhatnagar, Aseem; Baboota, Sanjula; Ali, Javed; Ahuja, Alka
• Is Part Of: Drug delivery. Volume 23:Number 3(2016:Apr.)
• Page Start: 923
• Page End: 929
• Publication Date: 2016-03-23
• Subjects: Brain targeting -- gamma scintigraphy -- intranasal drug delivery -- neural pathway -- non-neural pathway -- olfactory nerve -- ropinirole -- trigeminal nerve; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.3109/10717544.2014.923064
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: The effectiveness of intranasal drug delivery for brain targeting has emerged as a hope of remedy for various CNS disorders. The nose to brain absorption of therapeutic molecules claims two effective pathways, which include trans-neuronal for immediate action and para-neuronal for delayed action. To evaluate the contribution of both the pathways in absorption of therapeutic molecules and nanocarriers, lidocaine, a nerve-blocking agent, was used to impair the action potential of olfactory nerve. An anti-Parkinson drug ropinirole was covalently complexes with 99m Tc in presence of SnCl2 using in-house developed reduction technology. The radiolabeled formulations were administered intranasally in lidocaine challenged rabbit and rat. The qualitative and quantitative outcomes of neural and non-neural pathways were estimated using gamma scintigraphy and UHPLC-MS/MS, respectively. The results showed a significant ( p ≤ 0.005) increase in radioactivity counts and drug concentration in the brain of rabbit and rat compared to the animal groups challenged with lidocaine. This concludes the significant contribution ( p ≤ 0.005) of trans-neuronal and para-neuronal pathway in nose to brain drug delivery. Therefore, results proved that it is an art of a formulator scientist to make the drug carriers to exploit the choice of absorption pathway for their instant and extent of action.