Gold(i)-catalyzed redox transformation of o-nitroalkynes with indoles for the synthesis of 2, 3′-biindole derivatives. Issue 8 (25th February 2021)

• Record Type: Journal Article
• Authors: Zhou, Su; Liu, Qianqian; Bao, Ming; Huang, Jie; Wang, Junjian; Hu, Wenhao; Xu, Xinfang
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 8(2021)
• Page Start: 1808
• Page End: 1816
• Publication Date: 2021-02-25
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo00134e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A gold(i )-catalyzed cascade reaction of o -nitroalkynes with indoles has been reported for the rapid assembly of 2-indolyl indolone N -oxides, which exhibit high anticancer potency against SCLC cells. Abstract : An efficient and practical method for the synthesis of 2-indolyl indolone N -oxides via gold(i )-catalyzed cascade reaction of o -nitroalkynes with indoles has been reported. The generated product could be readily converted into the 2-indolylbenzoxazinone, which emits strong blue fluorescence. We also investigated the antitumor activity of these synthesized compounds in small cell lung cancer (SCLC), and the results show that compounds 3d and 4s exhibit high anticancer potency against SCLC cells.