Cover Feature: Protein Crystallography and Site‐Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis (ChemBioChem 14/2018). (27th June 2018)

• Record Type: Journal Article
• Authors: Liu, Bing; He, Lihui; Wang, Liping; Li, Tao; Li, Changcheng; Liu, Huayi; Luo, Yunzi; Bao, Rui
• Is Part Of: Chembiochem. Volume 19:Number 14(2018)
• Page Start: 1464
• Page End: 1464
• Publication Date: 2018-06-27
• Subjects: mutagenesis -- polymers -- protein engineering -- sustainable chemistry -- waste disposal; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201800330
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows that PETase, a newly discovered enzyme from Ideonella sakaiensis, has high efficiency and specificity towards PET plastics compared to other similar enzymes (such as cutinase, esterase, or lipase). We have analyzed its crystal structure and improved its catalytic efficiency through site mutagenesis. The results suggest that this enzyme has valuable potential for further study and applications. More information can be found in the communication by Y. Luo, R. Bao, et al. on page 1471 in Issue 14, 2018 (DOI: 10.1002/cbic.201800097 ).