PBC‐10: a short quality of life measure for clinical screening in primary biliary cholangitis. Issue 11 (30th October 2019)

• Record Type: Journal Article
• Authors: Alrubaiy, Laith; Mells, George; Flack, Steven; Bosomworth, Helen; Hutchings, Hayley; Williams, John; Jones, David
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 50:Issue 11/12(2019)
• Page Start: 1223
• Page End: 1231
• Publication Date: 2019-10-30
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.15554
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Current guidelines in primary biliary cholangitis ( PBC) recommend routine screening for symptoms. However, at present there are no validated practical tools suitable for screening use in practice. Aim: To develop a short quality of life questionnaire for PBC Methods: The short PBC HRQL questionnaire was derived and validated by analysing the PBC‐40 questionnaires from the UK‐PBC Research Cohort. Construct validity was assessed using the European Quality of Life Five Dimensions (EQ5D) questionnaire. Test‐retest analysis was done by asking a subgroup of patients to complete the questionnaire twice within 2‐4 weeks. Results: A total of 2219 patients completed PBC‐40 questionnaire in 2013. Stepwise regression identified 10 questions that contributed to more than 95% of the PBC‐40 score variance and covered the main domains of PBC. The short HRQL questionnaire, PBC‐10, had good internal consistency (Cronbach's α 0.905) and item‐total correlations. PBC‐10 demonstrated no ceiling effects but a floor effect was noted. Further validation on 2502 patients who completed the PBC questionnaire in 2017 confirmed the psychometric properties of PBC‐10. Further analysis on 186 patients showed that PBC‐10 demonstrated good internal consistency (Cronbach's α = 0.936), had good reproducibility (intra‐class correlation coefficient = 0.945), good correlation with the EQ5D ( r = .736), and was responsive to change. A change of 4 points in the PBC‐10 score would be considered clinically important. Conclusion: PBC‐10 is a short and valid questionnaire for assessing the HRQL in patients with PBC in clinical practice.