Synthesis of Highly Substituted Fluoro Chromenones in a "One‐Pot Four‐ Component Strategy" Using NFSI as a Fluorinating Reagent. Issue 47 (17th December 2019)

• Record Type: Journal Article
• Authors: Srikanth Reddy, Narra; Krishna Swaroop, Desireddy; Ravi Kumar, Nagiri; Sreenivas, Avula; Narsaiah, Banda
• Is Part Of: ChemistrySelect. Volume 4:Issue 47(2019)
• Page Start: 13768
• Page End: 13771
• Publication Date: 2019-12-17
• Subjects: Chromenones -- Electrophilic fluorination -- Fluoro imino chromenones -- Hydroxy fluoro amino chromenone -- Multicomponent reaction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201904090
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient one pot four component strategy has been developed for the synthesis of highly substituted fluoro chromenone derivatives (5 a‐p ) in good yields from β ‐aryl thio acetanilide, aldehydes, cyclic 1, 3‐diketones and NFSI ( N ‐Fluorobenzenesulfonimide) in presence of water. The fluoro imino chromenone intermediate 6 is isolated under the inert condition in high yield. Abstract : A series of novel highly substituted fluoro chromenone derivatives (5 a‐p) and fluoro imino chromenone (6 a‐c) derivatives were prepared from β ‐aryl thio acetanilide, aldehydes, cyclic 1, 3‐diketones and NFSI ( N ‐Fluorobenzenesulfonimide) through the one pot four components strategy. The developed one pot four component approach was utilized for the synthesis of various fluoro imino chromenones (6 a‐c) under mild reaction conditions. This transformation allowed all the substrates having different electronic properties to furnish the desired products in moderate to good yield.