Evaluation of radiomic texture feature error due to MRI acquisition and reconstruction: A simulation study utilizing ground truth. (June 2018)

• Record Type: Journal Article
• Authors: Yang, Fei; Dogan, Nesrin; Stoyanova, Radka; Ford, John Chetley
• Is Part Of: Physica medica. Volume 50(2018)
• Page Start: 26
• Page End: 36
• Publication Date: 2018-06
• Subjects: Radiomics -- Texture -- MRI -- Repeatability; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2018.05.017
• Languages: English
• ISSNs: 1120-1797

Abstract

Highlights: MRI simulation was utilized to measure texture dependence on MR acquisition details. Texture was measured on a digital brain phantom and clinical brain images. Texture depends on noise, reconstruction algorithm, and parallel imaging R-factor. Some texture features can be very different from the ground truth values. Texture features are more or less robust and some predict high vs low grade glioma. Abstract: The purpose of this study was to examine the dependence of image texture features on MR acquisition parameters and reconstruction using a digital MR imaging phantom. MR signal was simulated in a parallel imaging radiofrequency coil setting as well as a single element volume coil setting, with varying levels of acquisition noise, three acceleration factors, and four image reconstruction algorithms. Twenty-six texture features were measured on the simulated images, ground truth images, and clinical brain images. Subtle algorithm-dependent errors were observed on reconstructed phantom images, even in the absence of added noise. Sources of image error include Gibbs ringing at image edge gradients (tissue interfaces) and well-known artifacts due to high acceleration; two of the iterative reconstruction algorithms studied were able to mitigate these image errors. The difference of the texture features from ground truth, and their variance over reconstruction algorithm and parallel imaging acceleration factor, were compared to the clinical "effect size", i.e., the feature difference between high- and low-grade tumors on T1- and T2-weighted brain MR images of twenty glioma patients. The measured feature error (difference from ground truth) was small for some features, but substantial for others. The feature variance due to reconstruction algorithm and acceleration factor were generally smaller than the clinical effect size. Certain texture features may be preserved by MR imaging, but adequate precautions need to be taken regarding their validity and reliability. We present a general simulation framework for assessing the robustness and accuracy of radiomic textural features under various MR acquisition/reconstruction scenarios.