Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Neumann, J.; Hofmann, F.C.; Heilmeier, U.; Ashmeik, W.; Tang, K.; Gersing, A.S.; Schwaiger, B.J.; Nevitt, M.C.; Joseph, G.B.; Lane, N.E.; McCulloch, C.E.; Link, T.M.
• Is Part Of: Osteoarthritis and cartilage. Volume 26:Issue 6(2018)
• Page Start: 751
• Page End: 761
• Publication Date: 2018-06
• Subjects: Knee osteoarthritis -- Diabetes mellitus -- Cartilage imaging -- Magnetic resonance imaging -- Biomarkers; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2018.03.010
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Purpose: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. Methods: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren–Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. Results: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m 2, P = 0.52), sex (female 53.6% vs 54.1%, P = 0.92) and KL score distribution ( P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39, 1.19]) ( P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer ( P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values ( P < 0.05), indicating a more disordered cartilage composition. Conclusion: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.