Controlled synthesis of L-cysteine coated cobalt ferrite nanoparticles for drug delivery. Issue 12 (15th August 2018)

• Record Type: Journal Article
• Authors: Wang, Guangshuo; Zhou, Fei; Li, Xiaoguang; Li, Jinlin; Ma, Yingying; Mu, Jingbo; Zhang, Zhixiao; Che, Hongwei; Zhang, Xiaoliang
• Is Part Of: Ceramics international. Volume 44:Issue 12(2018)
• Page Start: 13588
• Page End: 13594
• Publication Date: 2018-08-15
• Subjects: Cobalt ferrite -- L-cysteine -- Superparamagnetic -- Biocompatible -- Controlled drug delivery; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2018.04.193
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: In the present work, we reported a facile synthesis of cobalt ferrite (CoFe2 O4 ) nanoparticles in the presence of L -cysteine (Lys). The morphology and size of samples were characterized by SEM and TEM. The successful coating of Lys on the surface of CoFe2 O4 was confirmed by XRD, XPS and TGA. The investigation of magnetic properties showed that both bare CoFe2 O4 and Lys-coated CoFe2 O4 nanoparticles exhibited room-temperature superparamagnetic behavior. The results of MTT experiments revealed insignificant cytotoxicity of Lys-coated CoFe2 O4 nanoparticles even after 24 h incubation. More importantly, Lys-coated CoFe2 O4 nanoparticles displayed an excellent drug loading capacity and a pH-sensitive drug release behavior. In summary, the prepared Lys-coated CoFe2 O4 nanoparticles demonstrated a promising application potential in controlled drug delivery.