Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms. (August 2018)

• Record Type: Journal Article
• Authors: Tan, Xiao; Chapman, Colin D.; Cedernaes, Jonathan; Benedict, Christian
• Is Part Of: Sleep medicine reviews. Volume 40(2018)
• Page Start: 127
• Page End: 134
• Publication Date: 2018-08
• Subjects: Long sleep duration -- Type 2 diabetes mellitus -- Obesity -- Putative mechanisms -- Chronotype -- Positive feedback loop; BMI body mass index -- GLP-1 glucagon-like peptide 1 -- IL-6 interleukin-6 -- NHANES US National health and nutrition examination survey -- OSA obstructive sleep apnea -- PSQI Pittsburgh sleep quality index -- REM rapid-eye movement -- SWS slow-wave sleep -- T2DM type 2 diabetes mellitus -- TNFα tumor necrosis factor alpha; Sleep disorders -- Periodicals; Sleep Disorders -- Periodicals; Sommeil, Troubles du -- Périodiques; Electronic journals; 616.8498
• DOI: 10.1016/j.smrv.2017.11.001
• Languages: English
• ISSNs: 1087-0792

Abstract

Summary: For the last two decades research has revealed an alarming association between short sleep duration and metabolic disorders. In tandem, the hormonal, behavioral, and genetic mechanisms underlying this relationship have been extensively investigated and reviewed. However, emerging evidence is revealing that excessive sleep duration has remarkably similar deleterious effects. Unfortunately, to date there has been little attention to what drives this connection. This narrative review therefore aims to summarize existing epidemiological findings, experimental work, and most importantly putative molecular and behavioral mechanisms connecting excessive sleep duration with both obesity and type 2 diabetes mellitus. It will also address recent findings suggesting a worrisome bidirectional effect such that metabolic disorders create a positive feedback loop which further perpetuates excessive sleep.