Application of resequencing microarrays in microbial detection and characterization. (May 2012)

• Record Type: Journal Article
• Authors: Leski, Tomasz A; Lin, Baochuan; Malanoski, Anthony P; Stenger, David A
• Is Part Of: Future microbiology. Volume 7:Number 5(2012)
• Page Start: 625
• Page End: 637
• Publication Date: 2012-05
• Subjects: broad-range microbial detection -- high-density microarrays -- microbial characterization -- microbial diagnostics -- resequencing microarrays; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.12.30
• Languages: English
• ISSNs: 1746-0913

Abstract

Microarrays are powerful, highly parallel assays that are transforming microbiological diagnostics and research. The adaptation of microarray-based resequencing technology for microbial detection and characterization resulted in the development of a number assays that have unique advantages over other existing technologies. This technological platform seems to be especially useful for sensitive and high-resolution multiplexed diagnostics for clinical syndromes with similar symptoms, screening environmental samples for biothreat agents, as well as genotyping and whole-genome analysis of single pathogens.