An insight into the anti-inflammatory properties of edible and medicinal mushrooms. (August 2018)

• Record Type: Journal Article
• Authors: Du, Bin; Zhu, Fengmei; Xu, Baojun
• Is Part Of: Journal of functional foods. Volume 47(2018)
• Page Start: 334
• Page End: 342
• Publication Date: 2018-08
• Subjects: Mushroom -- Anti-inflammatory activity -- In vitro model -- Animal model -- Chemopreventive property -- Therapeutic potential; CD Crohn's disease -- ConA concanavalin A -- COX-1 cyclooxygenase-1 -- COX-2 cyclooxygenase-2 -- DAI disease activity index -- DSS dextran sulfate sodium -- G-CSF granulocyte colony-stimulating factor -- GM-CSF granulocyte-macrophage colony stimulating factor -- IFN-γ interferon-γ -- IL-6 interleukin-6 -- Inos inducible nitric oxide synthase -- LOX lipoxygenase -- LPS lipopolysacharide -- MAPKs mitogen-activated protein kinases -- MCP monocyte chemotactic protein -- MMPs matrix metalloproteinases -- NO nitric oxide -- NF-κB nuclear factor kappa-B -- PGE 2 prostaglandin E 2 -- ROS reactive oxygen species -- STAT signal transducers and activators of transcription -- TNF-α tumor necrosis factor-α -- UC ulcerative colitis; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.06.003
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: The anti-inflammatory properties of mushrooms were summarized. The cell model and animal model of anti-inflammatory activity were reviewed. Mechanisms of anti-inflammatory activity of mushrooms were summarized. Clinical studies on anti-inflammatory activity of mushroom were presented. Abstract: Background: Mushrooms have been valuable as edible and medical provisions for humankind. It is attributed not only to the quality of their taste but also to their biological activities. The extracts, compounds, and metabolites have a lot of biological activities such as antidiabetic, antioxidative, antitumor, and anti-inflammatory effects. The potent anti-inflammatory activity is associated with a multitude of signaling pathways. However, there are a few review papers on the anti-inflammatory activity of mushrooms. Scope and approach: Herein, the anti-inflammatory potential of mushroom is critically discussed using in vitro and animal models. Moreover, the mechanisms of anti-inflammatory activity are summarized. The current status of clinical studies evaluating anti-inflammatory activity of mushroom is also presented. Key findings and conclusion: It is believed that insights about these advances may encourage researchers to discover new phytochemical components and further study specific bioactivities of mushroom.