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An expeditious access of 2, 5′-dioxo-5′, 6′, 7′, 8′-tetrahydro-1′H-spiro[indoline-3, 4′-quinoline]-3′-carboxylate by reaction of isatin, ethyl cyanoacetate and enaminone in water. Issue 27 (5th July 2018)
Record Type:
Journal Article
Title:
An expeditious access of 2, 5′-dioxo-5′, 6′, 7′, 8′-tetrahydro-1′H-spiro[indoline-3, 4′-quinoline]-3′-carboxylate by reaction of isatin, ethyl cyanoacetate and enaminone in water. Issue 27 (5th July 2018)
Main Title:
An expeditious access of 2, 5′-dioxo-5′, 6′, 7′, 8′-tetrahydro-1′H-spiro[indoline-3, 4′-quinoline]-3′-carboxylate by reaction of isatin, ethyl cyanoacetate and enaminone in water
Abstract: We have demonstrated three component reaction of isatin, enaminone and ethyl cyanoacetate leading to sprirooxindole scaffold without catalyst in water. The synthetic protocol has several advantages like wide substrate scope, atom-economy and operationally simple experimental procedures which provides rapid access to library of compounds. The mechanistic details of the reaction has been investigated during the course of study. Graphical abstract: Image 1