The beneficial effects of HDL-C on atherosclerosis: rationale and clinical results. (April 2011)

• Record Type: Journal Article
• Authors: Santos-Gallego, Carlos G; Torres, Francisco; Badimóón, Juan Joséé
• Is Part Of: Clinical lipidology. Volume 6:Number 2(2011)
• Page Start: 181
• Page End: 208
• Publication Date: 2011-04
• Subjects: apoA-I -- atherosclerosis -- CETP inhibitor -- fibrates -- HDL -- HDL functionality -- LDL -- niacin -- phosphate -- phospholipids -- reverse cholesterol transport -- sphingosine-1 -- triglycerides; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/clp.10.90
• Languages: English
• ISSNs: 1758-4299

Abstract

Population studies have consistently demonstrated an inverse association between HDL-C and the risk of coronary heart disease. As a result, HDL-C is gaining increasing interest as a therapeutic target. In this article, we review the mechanism of action for the postulated antiatherogenic effect of HDL-C and how current and future therapies can exploit this beneficial activity. The clinical evidence supporting various interventions to raise HDL-C, from lifestyle modifications to established drugs (e.g., niacin and fibrates) is reviewed. Finally, we discuss new and promising approaches to enhance HDL-C.