Effect of endothelial dysfunction on the pathogenesis of urolithiasis in patients with metabolic syndrome. (9th April 2021)

• Record Type: Journal Article
• Authors: Yazici, Ozgur; Narter, Fehmi; Erbin, Akif; Aydin, Kadriye; Kafkasli, Alper; Sarica, Kemal
• Is Part Of: Aging male. Volume 23:Number 5(2020)
• Page Start: 1082
• Page End: 1087
• Publication Date: 2021-04-09
• Subjects: Brachial artery flow-mediated dilation -- endothelium -- endothelial dysfunction -- metabolic sydrome -- urolithiasis; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2019.1675151
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objective: The aim of the present prospective clinical study was to investigate the possible effect of endothelial dysfunction in urolithiasis. Methods: The study included 92 patients older than 18 years. The patients were divided into 4 groups with 23 patients each as group 1: metabolic sydrome (MetS) (−) stone disease (SD) (−), group 2: MetS (−) SD (+), group 3: MetS (+) SD (−) and group 4: MetS (+) SD (+). C-reactive protein, homocysteine, uric acid, and creatinine levels were evaluated between the groups. Endothelial (dys)function was evaluated based on the brachial artery flow-mediated dilation (FMD) measurement. Results: The mean age was 41.9 ± 10.2 (range, 18–62) years. Mean FMD value was 15.9 ± 18.2% (range, 24.0–68.5%). A strong significant difference was found between group 1 and 2 ( p < .001); group 1 and 3 ( p < .001) and group 1 and 4 ( p < .001) with regard to FMD. Conclusion: These results suggest that endothelial dysfunction plays an important role in the pathogenesis of urolithiasis in patients with MetS.