Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model. (9th April 2021)

• Record Type: Journal Article
• Authors: Da Silva, Marcello H. A.; Medeiros, Jorge L.; Costa, Waldemar S.; Sampaio, Francisco J. B.; De Souza, Diogo B.
• Is Part Of: Aging male. Volume 23:Number 5(2020)
• Page Start: 1009
• Page End: 1015
• Publication Date: 2021-04-09
• Subjects: Benign prostatic hyperplasia -- dutasteride -- erectile dysfunction -- sildenafil -- penis; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2019.1653839
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objective: The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model. Methods: Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering p values <.05 as significant. Results: The smooth muscle density decreased by 28.6% and 21.4% in BPH + D and BPH + DS, respectively, when compared to the BPH group. The sinusoid space density reduced by 32.2% in BPH, when compared to the Ctrl group; this density was also reduced by 22.6% in BPH + D, when compared to the BPH group. The density of the elastic fibers increased 51.6% and 65.6% in BPH + D and BPH + DS, when compared to the BPH group. Conclusion: Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil did not prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.