Rh(III)-catalyzed, 1, 2, 3-triazole-assisted directed CH coupling with diazo diphosphonates. Issue 29 (18th July 2018)

• Record Type: Journal Article
• Authors: Yu, Zhu-Jun; Zhang, Chen; Li, Jiang-Lian; Liu, Yan-Zhao; Yu, Xin-Ling; Guo, Li; Li, Guo-Bo; Wu, Yong
• Is Part Of: Tetrahedron letters. Volume 59:Issue 29(2018)
• Page Start: 2816
• Page End: 2819
• Publication Date: 2018-07-18
• Subjects: 1, 2, 3-Triazole -- C-H activation -- Rhodium-catalyzed -- Bisphosphonate -- Carbenoid; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.06.022
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: 1, 2, 3-Triazole was used as the direct group for CH carbenoid coupling reactions. A step- and atom economical protocol constructing CC bond was developed. Bisphosphonates motifs, a unique pharmacophore, were easily assembled to arenes. Abstract: A mild and efficient procedure was developed for the [Cp∗Rh(III)]-catalyzed, 1, 2, 3-triazole directed CH coupling with diazomethylene-diphosphonates. This protocol provided a step- and atom-economical protocol for CC bond formation and led to structurally diverse 2-(1, 2, 3-triazol-2-yl)benzyl diphosphonates in good to excellent yields.