Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. (5th February 2021)

• Record Type: Journal Article
• Authors: Molloy, Síle F; Ross, Brad; Kanyama, Cecilia; Mfinanga, Sayoki; Lesikari, Sokoine; Heyderman, Robert S; Kalata, Newton; Ellis, Jayne; Kouanfack, Charles; Chanda, Duncan; Temfack, Elvis; Lakhi, Shabir; Moodley, Anand; Chan, Adrienne K; van Oosterhout, Joep J; Mapoure, Yacouba; Mwaba, Peter; Lalloo, David G; Wang, Duolao; Lortholary, Olivier; Jaffar, Shabbar; Hosseinipour, Mina C; Loyse, Angela; Harrison, Thomas S; Bicanic, Tihana
• Is Part Of: Open forum infectious diseases. Volume 8:Number 4(2021)
• Publication Date: 2021-02-05
• Subjects: cryptococcal meningitis -- fungal burden -- HIV -- raised intracranial pressure -- visual loss; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab066
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2 O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.