Hereditary and breastfeeding factors are positively associated with the aetiology of mammary gland hyperplasia: a case–control study. Issue 3 (18th June 2020)

• Record Type: Journal Article
• Authors: Gao, Hanlu; Yang, Chao; Fan, Jinqing; Lan, Li; Pang, Da
• Is Part Of: International health. Volume 13:Issue 3(2021)
• Page Start: 240
• Page End: 247
• Publication Date: 2020-06-18
• Subjects: breastfeeding duration -- family history of breast cancer -- hyperplasia of mammary gland -- interaction effect -- reproductive factors; World health -- Periodicals; Public health -- Developing countries -- Periodicals; Medical care -- Developing countries -- Periodicals; Medical policy -- Developing countries -- Periodicals; 362.1091724
• DOI: 10.1093/inthealth/ihaa028
• Languages: English
• ISSNs: 1876-3413

Abstract

Abstract: Background: Hyperplasia of mammary gland (HMG) has become a common disorder in women. A family history of breast cancer and female reproductive factors may work together to increase the risk of HMG. However, this specific relationship has not been fully characterized. Methods: A total of 1881 newly diagnosed HMG cases and 1900 controls were recruited from 2012 to 2017. Demographic characteristics including female reproductive factors and a family history of breast cancer were collected. A multi-analytic strategy combining unconditional logistic regression, multifactor dimensionality reduction (MDR) and crossover approaches were applied to systematically identify the interaction effect of family history of breast cancer and reproductive factors on HMG susceptibility. Results: In MDR analysis, high-order interactions among higher-level education, shorter breastfeeding duration and family history of breast cancer were identified (odds ratio [OR] 7.07 [95% confidence interval {CI} 6.08 to 8.22]). Similarly, in crossover analysis, HMG risk increased significantly for those with higher-level education (OR 36.39 [95% CI 11.47 to 115.45]), shorter duration of breastfeeding (OR 27.70 [95% CI 3.73 to 205.70]) and a family history of breast cancer. Conclusion: Higher-level education, shorter breastfeeding duration and a family history of breast cancer may synergistically increase the risk of HMG.